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Oct 15, 2013 · Immature myeloid-derived suppressor cells (MDSC), known to accumulate in tumor-bearing mice and cancer patients, are site-specific inflammatory and T cell immunosuppressive effector cells that contribute to cancer progression (15, 16). Ttl master apk
NOD-like receptor (NLR) proteins are intracellular innate immune sensors/receptors that regulate immunity. This work shows that NLRX1 serves as a tumor suppressor in colitis-associated cancer (CAC) and sporadic colon cancer by keeping key tumor promoting pathways in check.

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Aug 01, 2004 · It has been reported that tumor suppressors p53 and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are capable of inhibiting AR-dependent transcription from the PSA promoter (43, 44). Furthermore, LATS2 expression can be induced by p53 ( 45 ), suggesting that a possible connection exists between p53, PTEN, LATS2, and the ...

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Sep 25, 2012 · Exosomes are microvesicles of endosomal origin that are secreted, and their contents (proteins, lipids, DNA, or microRNAs) can alter the physiological states of recipient cells. We demonstrated that phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a tumor suppressor protein normally localized in the cytoplasm and nucleus, was secreted in exosomes. Secreted PTEN was internalized ...

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